Tuning the Elasticity of Nanogels Improves Their Circulation Time by Evading Immune Cells

Peptide receptor radionuclide therapy is used to treat solid tumors by locally delivering radiation. However, due nephro- and hepato-toxicity, it limited its dosage. To amplify radiation damage tumor cells, radiolabeled nanogels can be used. We show that tuning the mechanical properties of significant enhancement in circulation half-life gel could achieved. demonstrate why how small changes influence cellular fate. Nanogels with a storage modulus 37 kPa were minimally phagocytosed monocytes macrophages compared 93 modulus. Using PET/CT difference blood time was shown. Computer simulations affirmed results predicted mechanism uptake nanogels. Altogether, this work emphasizes important role elasticity even for particles are inherently soft such as nano- or microgels.